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SD-208

品牌
Sigma-Aldrich
CAS
627536-09-8
货号
S7071
规格纯度
≥98% (HPLC), powder
参考价格
1885.18 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2

包装

5, 25 mg in glass bottle

生化/生理作用

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
SD-208 is TGF-βR I kinase inhibitor with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

基本信息

经验(实验)分子式C17H10ClFN6
分子量352.75
MDL编号MFCD11519969
PubChem化学物质编号24899731
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 off-white to tan
溶解性DMSO: >5 mg/mL
储存温度2-8℃
SMILES stringFc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2
InChI1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChI keyBERLXWPRSBJFHO-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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