产品说明
应用
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
包装
5, 25 mg in glass bottle
生化/生理作用
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
SD-208 is TGF-βR I kinase inhibitor with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.
基本信息
经验(实验)分子式 | C17H10ClFN6 |
分子量 | 352.75 |
MDL编号 | MFCD11519969 |
PubChem化学物质编号 | 24899731 |
NACRES | NA.77 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
颜色 | off-white to tan |
溶解性 | DMSO: >5 mg/mL |
储存温度 | 2-8℃ |
SMILES string | Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2 |
InChI | 1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25) |
InChI key | BERLXWPRSBJFHO-UHFFFAOYSA-N |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H302 |
危险分类 | Acute Tox. 4 Oral |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |