产品介绍：
产品说明
应用
PP2 has been used:
- to analyze the effects of Src/focal adhesion kinase (FAK) signaling on IQ domain GTPase-activating protein 1 (IQGAP1)-mediated anoikis resistance
- for Src inhibition to study its effect on epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in non-small cell lung cancer (NSCLC) cells
- for pharmacological inhibition of SRC in MDA-MB-231 breast cancer cells
包装
5 mg in glass bottle
生化/生理作用
PP2 is a selective inhibitor of Src-family tyrosine kinases of non-receptor tyrosine kinases (nRTK). It shows >10,000-fold selectivity over Zeta-chain-associated protein kinase 70 (ZAP-70) and Janus kinase 2 (JAK2). PP2 effectively reduces cervical cancer proliferation in vitro and in vivo.
特点和优势
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
该化合物由 Pfizer 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。
基本信息
| 经验(实验)分子式 | C15H16ClN5 |
| 分子量 | 301.77 |
| MDL编号 | MFCD01568210 |
| PubChem化学物质编号 | 329819994 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to off-white |
| 溶解性 | DMSO: >10 mg/mL |
| 创始人 | Pfizer |
| 储存温度 | 2-8℃ |
| SMILES string | CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13 |
| InChI | 1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) |
| InChI key | PBBRWFOVCUAONR-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 |
| 预防措施声明 | P301 + P310 |
| 危险分类 | Acute Tox. 3 Oral |
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
