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SB-3CT

品牌
Sigma-Aldrich
CAS
292605-14-2
货号
S1326
规格纯度
≥98% (HPLC), powder
参考价格
3319.3 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

SB−3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation.

包装

5, 25 mg in glass bottle

生化/生理作用

SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM).

法律信息

Sold under license of U.S. Patent 6,703,415.

基本信息

经验(实验)分子式C15H14O3S2
分子量306.40
MDL编号MFCD09836266
PubChem化学物质编号329824474
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to off-white
溶解性DMSO: >20 mg/mL
储存温度−20℃
SMILES stringO=S(=O)(CC1CS1)c2ccc(Oc3ccccc3)cc2
InChI1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
InChI keyLSONWRHLFZYHIN-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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