产品说明
应用
E3330 has been used in the inhibition of endothelial cancer cells and apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1).
包装
5, 25 mg in glass bottle
生化/生理作用
E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.
基本信息
| 经验(实验)分子式 | C21H30O6 |
| 分子量 | 378.46 |
| MDL编号 | MFCD00901331 |
| PubChem化学物质编号 | 329799080 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | red to orange |
| 溶解性 | DMSO: >20 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | CCCCCCCCC\C(=C/C1=C(C)C(=O)C(OC)=C(OC)C1=O)C(O)=O |
| InChI | 1S/C21H30O6/c1-5-6-7-8-9-10-11-12-15(21(24)25)13-16-14(2)17(22)19(26-3)20(27-4)18(16)23/h13H,5-12H2,1-4H3,(H,24,25)/b15-13+ |
| InChI key | AALSSIXXBDPENJ-FYWRMAATSA-N |
安全信息
| 危险声明 | H413 |
| 危险分类 | Aquatic Chronic 4 |
| 储存分类代码 | 11 - Combustible Solids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
