产品说明
一般描述
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM) and myosin light chain kinase (IC50 = 51 µM).
包装
10 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Primary Target
Myosin light chain kinase
Product does not compete with ATP.
Reversible: yes
Target IC50: 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase
警告
Toxicity: Standard Handling (A)
其他说明
Caulfield, M.P., et al. 1991. Neurosci. Lett.125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther.251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem.96, 1721.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C16H21ClN2O2S · xHCl |
| 分子量 | 340.87 (free base basis) |
| MDL编号 | MFCD00012559 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (TLC) |
| 形式 | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 5 mg/mL DMF: soluble warm ethanol: soluble |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H |
| InChI key | OMMOSRLIFSCDBL-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
