位置:首页 > 品牌 > Sigma-Aldrich >

Carbonic Anhydrase Isozyme II human

品牌
Sigma-Aldrich
CAS
9001-03-0
货号
C6165
规格纯度
≥80%, powder, ≥3,000 W-A units/mg protein
参考价格
6756.27 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Human carbonic anhydrase isozyme II has been used to assess its gene fusion abilities for efficient expression and recovery of recombinant proteins. Human carbonic anhydrase isozyme II has also been used to investigate a new process for the synthesis of difluoromethanesulfonamides. Furthermore, CA II from Sigma has been used as a standard to measure the CA activity in lung tissue homogenates. The study analysed the possible relationship between the expression of carbonic anhydrase and non-small cell lung cancer. The product has also been used with Freund′s complete adjuvant at 1:1 ratio for antibody production. This study evaluated the quantitative and functional alterations of cytosolic CA isoenzymes in the erythrocytes of glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. The enzyme has also been used in the study of natural phenolic inhibitors of CA II.

包装

1, 5, 25 mg in glass bottle

生化/生理作用

Carbonic anhydrase is a zinc metalloenzyme that catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in pathological and physiological processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors that can be used for treating various pathological conditions such as glaucoma, epilepsy and Parkinson′s disease. CAII has a molecular mass of approximately 30 kDa and is primarily present in type II pneumocytes. Due to this unique location it has been speculated that CAII is involved in pulmonary functions such as regulation of fluid secretion and CO2 elimation. Sulfonamides, sulfamates and sulfamides are potent inhibitors of CA.

单位定义

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 ℃. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

基本信息

酶学委员会(EC)编号4.2.1.1 ( BRENDA | IUBMB )
EC 号232-576-6
MDL编号MFCD00081467
NACRESNA.54

产品性质

质量水平200
测定≥80%
形式powder
specific activity≥3,000 W-A units/mg protein
分子量 30 kDa
颜色 white
pI ~7.4
UniProt登记号P00918
储存温度−20℃
Gene Informationhuman ... CA2(760)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号