产品说明
一般描述
This kit minimizes laboratory setup with optimized protocols and step-by-step instructions for synthesizing drug-encapsulated nanoparticle-based formulations. Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible and biodegradable polymer that has been approved by the FDA for biomedical and pharmaceutical applications. PLGA based nanoparticles have been widely used as drug delivery systems for different types of therapeutic molecules, to achieve controlled drug release.
Protocols for two different particle synthesis methods are included.
- A Nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
- A Microfluidics protocol using commercial platforms or syringe pumps.
The microfluidics protocol uses NanoFabTx™ device kits (911593), which provide all the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).
应用
NanoFabTx™ PEG-PLGA drug loading screening kit is a ready-to-use nanoformulation kit for the synthesis of PEGylated PLGA nanoparticles. This kit provides properly selected PEGylated PLGAs, stabilizer and formulation protocol for synthesis by nanoprecipitation and microfluidic methods. Four different PEGylated PLGAs are included in this kit, allowing rapid screening of optimal materials for enhancing drug loading. NanoFabTx™ nanoformulation reagent kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.
特点和优势
- Ready-to-use nanoformulation kit for PEGylated PLGA nanoparticles
- Choose from either nanoprecipitation or microfluidics-based protocols
- Create specifically sized, biodegradable, PEGylated PLGA nanoparticles
- Maximize the encapsulation of hydrophobic drugs
- Four different PEGylated PLGAs are included
法律信息
NANOFABTX is a trademark of sigma-aldrich Co. LLC
产品性质
| 描述 | Drug loading screening kit, for synthesis of PEGylated PLGA nanoparticles Kit components : PEGPLGA-50L(912808-500mg) PEGPLGA-75L(913049-500mg) PEGPLGA-50H (915955-500mg) PEGPLGA-75H (915718-500mg) Stabilizer-Nano (907766-5g) |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
