产品说明
一般描述
A pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (ECmax = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (ECmax = 55 µM). Exhibits anti-leishmanial effects.
A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.
包装
1 g in Plastic ampoule
Packaged under inert gas
生化/生理作用
Target IC50: ~11 µM causing 99% inhibition of protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1)
Product does not compete with ATP.
Reversible: yes
Primary Target
PTPase activity, including Src homology PTPase-1 (SHP-1)
Cell permeable: no
警告
Toxicity: Standard Handling (A)
制备说明
Heating to 75°C with constant stirring or constant stirring overnight at room temperature may be required for complete solubilization.
重悬
Unstable in solution; reconstitute just prior to use.
其他说明
Wortmann, G., et al. 2002. Clin. Infect. Dis.35, 261.
Pathak, M.K. and Yi, T. 2001. J. Immunol.167, 3391.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C12H17O17Sb2 · 3Na · 9H2O |
| 分子量 | 907.88 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥90% dry basis (≥30% Sb content, titration) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated protect from light |
| 颜色 | white |
| 溶解性 | water: 1 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/2C6H10O7.3Na.9H2O.3O.2Sb/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h2*2-5,7-8,10H,1H2,(H,12,13);;;;9*1H2;;;;;/q2*-2;3*+1;;;;;;;;;;;;;2*+2/p-2/t2*2-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1 |
| InChI key | CUEDNFKBTFCOSV-UZVLBLASSA-L |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H302 + H332 - H411 |
| 预防措施声明 | P261 - P264 - P270 - P273 - P301 + P312 - P304 + P340 + P312 |
| 危险分类 | Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
