产品说明
一般描述
A potent and selective inhibitor of the src family of tyrosine kinases. Its action is similar to PP1. Selectively inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), and Hck (IC50 = 5 nM) compared to other tyrosine kinases, such as EGF-R (IC50 = 480 nM), JAK2 (IC50 >50 µM) or ZAP-70 (IC50 >100 µM). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM).
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
p56lck
Product competes with ATP.
Target IC50: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells
Cell permeable: no
Reversible: yes
警告
Toxicity: Irritant (B)
外形
A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529573) in DMSO.
重悬
Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
其他说明
Hanke, J.H., et al. 1996. J. Biol. Chem.271, 695.
Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C15H16ClN5 |
分子量 | 301.77 |
产品性质
质量水平 | 100 |
测定 | ≥95% (HPLC) |
形式 | liquid |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze protect from light |
颜色 | clear colorless |
运输 | wet ice |
储存温度 | −20℃ |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
闪点(C) | 87 ℃ - (Dimethylsulfoxide) |