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Calcineurin Autoinhibitory Peptide, Cell-permeable-Calbiochem

品牌
Sigma-Aldrich
货号
207001
规格纯度
The Calcineurin Autoinhibitory Peptide, Cell-permeable controls the biological activity of Mn2+-stimulated calcineurin activity. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
3736.22 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable peptide that consists of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction doamin (11R) and acts as an inhibitor of CaN phosphatase activity. Reported to block CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Also reported to protect neuronal cells from glutamate-induced cell death.
A cell-permeable peptide that is composed of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction domain (11R) and acts as an inhibitor of CaN phosphatase activity. Blocks CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Protects neuronal cells from glutamate-induced cell death.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Blocks CaN-dependent NFAT nuclear translocation
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

序列

Ac-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Met-Ala-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-NH₂

其他说明

Terada, H., et al. 2003. J. Neurochem.87, 1145.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C137H251N71O34S2
分子量3501.04

产品性质

质量水平100
测定≥98% (HPLC)
形式lyophilized solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色 white
溶解性water: 1 mg/mL
运输wet ice
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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