产品说明
一般描述
A highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 75 nM). Inhibits geranylgeranyltransferase I (IC50 = 24 µM) and II (IC50 = 24 µM) at much higher concentrations. Also inhibits Ras farnesylation in whole cells by ~90% at 10-100 µg/ml (25-250 µM). Resistant to cleavage by phosphorylation.
A cell permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µM. Resistant to cleavage by phosphorylation.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
包装
1 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Target IC50: 75 nM against Ftase
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
其他说明
Manne, V., et al. 1995. Drug Development Res.34, 121.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C17H28NO5P · 2Na |
| 分子量 | 403.36 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 颜色 | white |
| 溶解性 | water: ≥10 mg/mL |
| 运输 | ambient |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
