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Aprindine hydrochloride

N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride

品牌
Sigma-Aldrich
CAS
33237-74-0
货号
A7606
规格纯度
≥98% (HPLC), solid
参考价格
1746.39 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase.

包装

10, 50 mg in glass bottle

生化/生理作用

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C22H30N2 · HCl
分子量358.95
EC 号251-418-7
MDL编号MFCD01698392
PubChem化学物质编号329770937
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式solid
溶解性H2O: >10 mg/mL
储存温度2-8℃
SMILES stringCl.CCN(CC)CCCN(C1Cc2ccccc2C1)c3ccccc3
InChI1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H
InChI keyKIPFVRHNAAZJOD-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

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