产品说明
一般描述
Neurogenin 2 (NGN2) is a helix-loop-helix class of transcription factor. Transcription factors with bHLH motifs modulate critical events in the development of the mammalian neocortex. The transition from proliferation to neurogenesis involves a coordinate increase in the activity of proneural bHLH factors, including Neurogenin 2 and a decrease in the activity of Hes and Id factors. bHLH factors have key roles in corticogenesis, affecting the timing of differentiation and the specification of cell fate. Neurog2 controls neurogenesis in the embryonic cerebral cortex directly induces the expression of the small GTP-binding protein Rnd2 in newly generated mouse cortical neurons before they initiate migration.
特异性
Recognizes Neurogenin 2 (MATH4a), a Helix-loop-helix class of transcription factor.
免疫原
Synthetic peptide, amino acids 85-97 of mouse Neurogenin 2.
应用
Research Sub Category
Developmental Neuroscience
Neuronal & Glial Markers
This Anti-Neurogenin-2 Antibody is validated for use in ELISA, IC, IH, IH(P), WB for the detection of Neurogenin-2.
Research Category
Neuroscience
Western blot: 1-10 μg/mL using ECL.
Immunocytochemistry: Cat. # AB5682 detected Neurogenin-2 in PC12 cells at 1:500 dilution. It was also detected in paraformaldehyde-fixed differentiated human neural stem cells.
ELISA: 0.5-1 μg/mL using 1 mg/mL control peptide (Catalog Number AG352) per well.
Immunohistochemistry on paraffin sections has been reported by Lamolet, B. et al. (2004)
Optimal working dilutions must be determined by the end user.
目标描述
~28 kDa
联系
Replaces: AB9620
外形
Affinity purified immunoglobulin. Precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
储存及稳定性
Stable for 1 year at -70ºC from date of receipt.
分析说明
Control
Human brain Lysate.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | mouse, rat, human |
manufacturer/tradename | Chemicon® |
technique(s) | ELISA: suitable immunocytochemistry: suitable immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable western blot: suitable |
同位素/亚型 | IgG |
NCBI登记号 | NM_024019.2 |
UniProt登记号 | Q9H2A3 |
运输 | dry ice |
Gene Information | human ... NEUROG2(63973) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |