产品说明
一般描述
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
免疫原
A phospho specific peptide corresponding to residues surrounding S293 of human PDHA1
外形
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
产品性质
生物来源 | rabbit |
质量水平 | 100 |
antibody product type | primary antibodies |
克隆 | monoclonal |
形式 | liquid |
species reactivity | rat, mouse, human |
浓度 | 0.49 mg/mL |
technique(s) | immunohistochemistry: 1:50-1:200 western blot: 1:500-1:2000 |
UniProt登记号 | P08559 |
运输 | wet ice |
储存温度 | −20℃ |
Gene Information | human ... PDHA1(5160) |
安全信息
闪点(F) | Not applicable |
闪点(C) | Not applicable |