产品说明
一般描述
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
免疫原
A phospho specific peptide corresponding to residues surrounding Y402 of human PTK2B
外形
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | liquid |
| species reactivity | human, mouse |
| 浓度 | 0.755 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt登记号 | Q14289 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PTK2B(2185) |
安全信息
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
