产品说明
一般描述
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
免疫原
A phospho specific peptide corresponding to residues surrounding S621 of human Phospho-Raf1-S621
外形
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| antibody product type | primary antibodies |
| 克隆 | monoclonal |
| 形式 | liquid |
| species reactivity | rat, mouse, human |
| 浓度 | 1.3 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt登记号 | P04049 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... RAF1(5894) |
安全信息
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
