位置:首页 > 品牌 > Sigma-Aldrich >

Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody

品牌
Sigma-Aldrich
货号
MAB5680
规格纯度
clone 8-18C5, Chemicon®, from mouse
参考价格
7701.24 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG′s possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.

特异性

Membane associated region of MOG [Myelin oligodendrocyte glycoprotein].
May cross react with human and bovine based on sequence similarity.

免疫原

Rat cerebellar glycoproteins
Epitope: The antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG.

应用

Research Sub Category
Neuronal & Glial Markers
Research Category
Neuroscience
Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody is an antibody against Myelin Oligodendrocyte Glycoprotein (MOG) for use in FC, IC, IH & WB.

质量

Routinely evaluated by immunoblot.

目标描述

28 kDa

外形

Purified in PBS with 0.05% NaN3.
Format: Purified
Purified immunoglobulin

储存及稳定性

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

分析说明

Control
brain lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆8-18C5, monoclonal
species reactivityrat, mouse
manufacturer/tradenameChemicon®
technique(s)flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型IgG1
GenBank® accession no.M99485.1
UniProt登记号Q63345
运输wet ice

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号