Anti-MYOZAP Antibody

产品说明

一般描述

Myocardial zonula adherens protein, also known as GRINL1A upstream protein (Gup), and encoded by the gene name MYZAP or MYOZAP, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase–RhoA interacting protein (MRIP) and acts as an activator of Rhodependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, Nmethyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.

免疫原

KLH-conjugated synthetic peptide corresponding to the C-terminus of human MYOZAP.
Epitope: C-terminus

应用

Research Category
Cell Structure
Anti-MYOZAP Antibody detects level of MYOZAP & has been published & validated for use in MYOZAP.
Research Sub Category
Cytoskeleton

质量

Evaluated by Western Blotting in rat kidney tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected MYOZAP in rat kidney tissue lysate.

目标描述

~54 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 11 isoforms produced by alternative splicing ranging between ~44 kDa and ~54 kDa

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息