Anti-RARB antibody produced in rabbit

产品说明

一般描述

The retinoic acid receptor-β(RARB) gene is mapped to human chromosome 3p24.
RARB exist with three major isotypes, termed α, β and γ. It is involved in the hormone-independent transcriptional activation. It is expressed in the cytoplasm and sub-nuclear space that resemble nuclear bodies.

免疫原

Retinoic acid receptor β recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Anti-RARB antibody produced in rabbit has been used in immunohistochemical staining.

生化/生理作用

The retinoic acid receptor-β(RARB) may act as an important target in cancer research. It is involved in the development of cancer and is linked with various human cancer types.
RARB is a tumor suppressor gene. It interacts weakly with silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor protein. It plays a pivotal role in mediating the retinoid signaling during morphogenesis, development, and cell differentiation. RARB plays an important role in retinoic acid pathway during eye development and organogenesis. Any recessive and dominant mutation in RARB causes anophthalmia and/or microphthalmia and diaphragmatic hernia. The suppression of RARB by DNA methylation and EZH2 leads to the gene silencing during prostate tumorigenesis.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST84809.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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