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Anti-SHP-1 Antibody, clone HG213, rabbit monoclonal

品牌
Sigma-Aldrich
货号
MABT213
规格纯度
clone HG213, from rabbit, unconjugated
参考价格
5854.74 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Src Homology region 2 domain Phosphatase 1 (SHP-1) is also known as Protein Tyrosine Phosphatase 1C (PTP1C), Protein Tyrosine Phosphatase non-receptor type 6 (PTPN6), and Hematopoietic Cell Phosphatase (HCPH). SHP-1 is a SH2 domain-containing cytosolic tyrosine phosphatase characterized by a catalytic phosphatase domain of approximately 240 amino acids that selectively dephosphorylates tyrosine residues in proteins; the SH2 domains are critical for SHP-1 to bind to ITIM domains in inhibitory immunoreceptors. SHP-1 is highly expressed in hematopoietic tissues and has a negative impact on lymphocyte signaling. SHP-1 is implicated in the control of tyrosine kinase signaling pathways in cellular proliferation, with a potential role in cancer.

免疫原

Full-length glutathione transferase SHP-1 fusion protein, purified from bacteria.

应用

Research Category
Cell Structure
Anti-SHP-1 Antibody, clone HG213 detects level of SHP-1 & has been published & validated for use in WB.
Research Sub Category
Cytoskeletal Signaling

质量

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected SHP-1 in 10 µg of Jurkat cell lysate.

目标描述

~67 kDa observed.
3 isoforms exist with molecular weights between 63 kDa and 68 kDa

外形

Rabbit monoclonal supernatant without sodium azide.
Unpurified

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
Jurkat cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式unpurified
antibody product typeprimary antibodies
克隆HG213, monoclonal
species reactivityhuman
technique(s)western blot: suitable
NCBI登记号NP_002822
UniProt登记号P29350
运输wet ice

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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