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Anti-Rsk1 Antibody, clone 3G5.1

品牌
Sigma-Aldrich
货号
MABS826
规格纯度
clone 3G5.1, from mouse
参考价格
5426.21 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1; UniProt Q15418; also known as 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, p90-RSK 1, p90RSK1, p90S6K, Ribosomal S6 kinase 1, RSK-1, S6K-alpha-1) is encoded by the RPS6KA1 (also known as MAPKAPK1A, RSK1) gene (Gene ID 6195) in human. Ribosomal s6 kinases (RSKs) are serine/threonine kinases that play a role in mediating Mek1/2-Erk1/2 mitogen-activated protein (MAP) kinase pathway signaling events. There exist two types of RSKs, p70rsk (a.k.a. S6 Kinase or S6-H1 kinase) and p90rsk (a.k.a. MAPK-activated protein kinase). Six p90rsk-coding genes have been identified in human, RPS6KA1 (MAPKAPK1A, RSK1), RPS6KA2 (MAPKAPK1C, RSK3), RPS6KA3 (MAPKAPK1B, RSK2), RPS6KA4 (MSK2), RPS6KA5 (MSK1), and RPS6KA6 (RSK4). p90RSK1 is activated by sequential phosphorylation events, where it is first phosphorylated by Erk1/2 on the C-terminal kinase domain (CTKD) Thr573, leading to subsequent Ser380 phosphorylation in the N-terminal AGC kinase-type domain. Alternatively, Ser380 can be phosphorylated directly by MK2/3 independent of CTKD Thr573 phosphorylation.

特异性

Clone 3G5.1 target epitope sequence is present in all four human Rsk1 spliced isoforms reported by UniProt (Q15418).

免疫原

Epitope: Linker region between two kinase domains.
KLH-conjugated linear peptide corresponding to a sequence from the linker region between the two human Rsk1 kinase domains.

应用

Anti-Rsk1 Antibody, clone 3G5.1 is an antibody against Rsk1 for use in Western Blotting.

质量

Evaluated by Western Blotting in PC12 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Rsk1 in 10 µg of PC12 rat pheochromocytoma cell lysate.

目标描述

~85 kDa observed. 82.88 kDa (rat), 86.47 kDa (mouse), 82.72 kDa (human isoform 1), 83.93 kDa (human isoform 2), 72.70 kDa (human isoform 3), and 81.15 kDa (human isoform 4) calculated. Uncharacterized band(s) may appear in some lysates.

外形

Protein G purified.
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702

产品性质

质量水平100
生物来源mouse
抗体形式purified antibody
antibody product typeprimary antibodies
克隆3G5.1, monoclonal
species reactivityrat
species reactivity (predicted by homology)Xenopus (based on 100% sequence homology), chicken (based on 100% sequence homology), porcine (based on 100% sequence homology), human (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology)
technique(s)western blot: suitable
同位素/亚型IgG1κ
NCBI登记号NP_002944
UniProt登记号Q15418
Gene Informationhuman ... RPS6KA1(6195)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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