产品说明
一般描述
Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.
应用
Superoxide Dismutase from bovine erythrocytes has been used in a study to assess activity parameters in adjuvant-induced arthritis. Superoxide Dismutase from bovine erythrocytes has also been used in a study to simplify the process of purifying superoxide dismutases using charge-controlled hydrophobic chromatography on 10-carboxydecyl Sepharose.
包装
15000, 75000 units in glass bottle
生化/生理作用
催化超氧化物自由基的歧化反应生成过氧化氢和分子氧。在细胞防御氧自由基的毒性作用方面发挥着重要作用。与一氧化氮(NO)竞争超氧化物阴离子(可与NO反应生成过亚硝酸盐),因此SOD能促进NO的活性。在培养的大鼠卵泡、神经细胞系和转基因小鼠中,SOD也表现出抑制细胞凋亡的作用。
单位定义
One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 ℃ in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.
基本信息
酶学委员会(EC)编号 | 1.15.1.1 ( BRENDA | IUBMB ) |
EC 号 | 232-943-0 |
MDL编号 | MFCD00132404 |
NACRES | NA.54 |
产品性质
产品线 | BioUltra |
质量水平 | 200 |
测定 | ≥97% (SDS-PAGE) |
形式 | lyophilized powder |
specific activity | ≥4,500 units/mg protein |
分子量 | 32.5 kDa |
组成 | Protein, ≥95% biuret |
相关疾病 | arthritis |
储存温度 | −20℃ |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, type N95 (US) |