产品介绍：
产品说明
应用
SCH-28080 was used to treat zebrafish embryos to study the role of H+/K+-ATPase in establishment of left-right axis during development.
包装
10, 50 mg in glass bottle
生化/生理作用
SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.
基本信息
| 经验(实验)分子式 | C17H15N3O |
| 分子量 | 277.32 |
| MDL编号 | MFCD00834620 |
| PubChem化学物质编号 | 24278810 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 颜色 | white to light tan |
| 溶解性 | DMSO: soluble >10 mg/mL H2O: insoluble |
| 相容性 | for use with ABI 7700 |
| 储存温度 | −20℃ |
| SMILES string | Cc1nc2c(OCc3ccccc3)cccn2c1CC#N |
| InChI | 1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3 |
| InChI key | PYKJFEPAUKAXNN-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
