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β-Synuclein P123H histidine-tagged human

品牌
Sigma-Aldrich
货号
S6699
规格纯度
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
参考价格
7857.9 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missense mutations in neurodegeneration stimulation.

外形

Lyophilized from a 0.2 μm filtered solution.

重悬

Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at −20 ℃.

基本信息

MDL编号MFCD08705537
NACRESNA.32

产品性质

质量水平200
重组expressed in E. coli
测定≥90% (SDS-PAGE)
形式lyophilized powder
UniProt登记号Q16143
运输dry ice
储存温度−20℃
Gene Informationhuman ... SNCB(6620)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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