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MDM2, GST-tagged human

品牌
Sigma-Aldrich
货号
M0321
规格纯度
recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE)
参考价格
2208.08 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Murine double minute 2 (MDM2) encoding gene is localized at 12q15 in the human chromosome. It is a multidomain nuclear phosphoprotein. It possesses really interesting new gene (RING) finger domain and its function and structural integrity is required for the action of MDM2. It also has central acidic domain.

包装

10 μg in glass bottle

生化/生理作用

Overexpression of Murine double minute 2 (MDM2) is observed in various cancer like lung, gastric, colorectal, hepatocellular, breast, endometrial, and prostate. A common single nucleotide polymorphism is observed at 309 amino acid (from T to G) increases the susceptibility to cancer.
Murine double minute 2 (MDM2) is a chief regulator of the p53 tumor suppressor protein. It is a multifunctional oncoprotein that contributes to both p53-dependent and -independent roles in oncogenesis. MDM2 has various p53-independent functions that contribute to its activity as an oncogene.
MDM2 is a negative regulator of the p53 tumor suppressor.
Mdm2 functions as an E3 ubiquitin ligase and an inhibitor of p53 transcriptional activation.

外形

Solution in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF and 25% glycerol.

制备说明

Supplied as a truncated version (202-end) with an N-terminal GST tag

产品性质

质量水平200
生物来源human
重组expressed in E. coli
描述contains an N-terminal GST tag
测定≥75% (SDS-PAGE)
形式buffered aqueous glycerol solution
分子量 ~84 kDa
UniProt登记号Q00987
运输dry ice
储存温度−70℃
Gene Informationhuman ... MDM2(4193)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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