产品说明
一般描述
Matrix metalloproteinase-3 (MMP-3) is also known as stromelysin 1 and the gene encoding it is localized on human chromosome 11q22.3.
特异性
Reacts with reduced and to a lesser extent non-reduced MMP-3. The propeptide is shed after activation; therefore, the antibody recognizes the pro-form of MMP-3 and not the active forms. May be used to distinguish the latent from the active form of MMP-3. Recognizes Stromelysin-1 and Stromelysin-2, but not Stromelysin-3 or other MMP family members.
免疫原
synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-3 (stromelysin-1).
生化/生理作用
Matrix metalloproteinase-3 (MMP-3) plays an important role in cartilage degradation. It can act on a large number of substrates like type II, III, IV, IX and X collagens, laminin and fibronectin. MMP-3 can also activate other matrix metalloproteinases like MMP-1,-2 and -13. It has been associated with rheumatoid arthritis.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.
基本信息
| MDL编号 | MFCD03455413 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous glycerol solution |
| 分子量 | antigen 59 kDa antigen (pro-form) 57 kDa |
| species reactivity | human |
| 浓度 | ~1 mg/mL |
| technique(s) | western blot: 1:1000 |
| UniProt登记号 | P08254 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MMP3(4314) |
