产品说明
应用
Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2.
包装
5 mg in glass bottle
生化/生理作用
Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4.
Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).
特点和优势
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制备说明
Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.
基本信息
| 经验(实验)分子式 | C18H24N2OS |
| 分子量 | 316.46 |
| MDL编号 | MFCD00236450 |
| PubChem化学物质编号 | 24278728 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | 99% (HPLC) |
| 溶解性 | DMSO: soluble (at 26 mg/ml) H2O: insoluble |
| SMILES string | CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C |
| InChI | 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+ |
| InChI key | XRZYELWZLNAXGE-KPKJPENVSA-N |
| Gene Information | human ... ERBB2(2064), NTRK1(4914) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
