产品说明
生化/生理作用
PKCζ (protein kinase C ζ) is a atypical PKC and works independent of Ca2+ and diacylglycerol. It is involved in MAPK (mitogen-activated protein kinase)-induced nuclear factor κ B activation. It also stabilizes DNA mismatch-repair proteins, participates in laeukemic cell differentiation, cell migration and chemotaxis. PKCζ have tumour suppressor as well as oncogenic properties. Upregulation of PKCζ causes apoptosis in ovarian carcinoma cells. On the other hand, absence of PKCζ decreases tumorigenic activity in a colon cancer mouse model.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in baculovirus infected Sf9 cells |
| 产品线 | PRECISIO® Kinase |
| 测定 | ≥70% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | 97-131 nmol/min·mg |
| 分子量 | ~93 kDa |
| UniProt登记号 | Q05513 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... PRKCZ(5590) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
