Anti-mGluR2 Antibody

产品说明

一般描述

The metabotropic glutamate receptors belong to a family of G protein-coupled receptors that have been divided into 3 groups based on their sequence homology, putative signal transduction mechanisms, and pharmacologic properties. mGluR2 belongs to the Group II. It is widely expressed in different regions of fetal and the adult brain. Ligand binding to GluR2 induces a conformation change in the receptor, which triggers signaling to modulate the activity of down-stream effectors, mainly via the inhibition of adenylate cyclase activity. Activation of mGluR2 leads to inhibition of glutamate release at the synaptic junction

免疫原

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of mouse mGlur2.
Epitope: Cytoplasmic domain

应用

Anti-mGluR2 Antibody is an antibody against mGluR2 for use in Western Blotting, Immunoprecipitation.
Research Category
Neuroscience
Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated mGlur2 in 500 µg of rat brain microsomal prep.
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in rat brain microsomal prep.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected mGlur2 in 10 µg of rat brain microsomal prep.

目标描述

~95/200 kDa observed. The lower band corresponds to the calculated molecular weight of mGluR2 (~100 kDa) and the upper band is likely a receptor dimer and frequently appears in immunoblots of mGluRs (Reid and Romano, 2001; Romano et al., 1996).

联系

Replaces: 07-261

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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