产品说明
一般描述
NRN1 (neuritin 1) is a highly conserved extracellular GPI (glycosylphosphatidylinositol)-anchored protein that was initially identified in rat hippocampal dentate gyrus in a screening of candidate kainic acid-induced plasticity related genes. This protein is also secreted in a soluble form.
Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8kDa polypeptide monomers, each containing 89 amino acid residues.
生化/生理作用
NRN1 (neuritin 1) is implicated in synaptic plasticity during brain development, and is an activity-dependent protein. Synaptic plasticity is dependent upon neuronal migration, and a study shows that NRN1 protein facilitates neuronal cell migration, and its levels influence microtubule stability. This protein also promotes dendritic arborization and synapse maturation in the central nervous system (CNS). It facilitates the survival of neural progenitors and differentiated neurons during early embryonic development, and during late development it is responsible for the maturation and formation of synapses by promoting the growth and stabilization of axons and dendrites. Study in human microendothelial cells (HMEC-1) shows that the expression of this protein is hypoxia-induced, and it is a hypoxic perinecrotic marker.
Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8kDa polypeptide monomers, each containing 89 amino acid residues.
序列
MAGKCDAVFK GFSDCLLKLG DSMANYPQGL DDKTNIKTVC TYWEDFHSCT VTALTDCQEG AKDMWDKLRK ESKNLNIQGS LFELCGSGN
外形
Lyophilized with no additives.
重悬
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in E. coli |
| 测定 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
| 形式 | lyophilized |
| 效能 | 20.0-30.0 ng/mL ED50 |
| 分子量 | 9.7 kDa |
| 包装 | pkg of 20 μg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | <0.1 EU/μg endotoxin, tested |
| 颜色 | white to off-white |
| UniProt登记号 | Q9NPD7 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... NRN1(51299) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
