产品说明
一般描述
Calcitonin gene-related peptide (CGRP) is a vasodilator that belongs to the calcitonin family of peptides. It is produced by motor neurons of peripheral and central nervous system. There are two forms of CGRP, α and β, which exhibit similar functions. The effects of CGRP are mediated by G-protein coupled receptor heterodimer formed by calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein 1 (RAMP1). Several biological effects of CGRP are observed in nervous, endocrine, immune and cardiovascular systems. Multiple studies have implicated CGRP in the pathophysiology of migraine and antagonists to CGRP are being explored as treatment options
Monoclonal Anti-Calcitonin Gene-Related Peptide (CGRP) recognizes human and guinea pig CGRP. It does not cross react with rat CGRP.
免疫原
peptide corresponding to the C-terminal of rat α−calcitonin gene-related peptite (CGRP).
应用
Anti-Calcitonin Gene-Related Peptide (CGRP) antibody is suitable for immunohistochemistry at a working antibody dilution of 1:200 to 1:1000 using formalin-fixed, paraffin-embedded sections or cryostat tissue sections. The antibody may be used for immunofluorescence at a working dilution of 1:500.
外形
Solution in PBS containing 1% BSA and ≤ 0.1% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD00162203 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | CD8, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | guinea pig, human |
| technique(s) | immunocytochemistry: suitable immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1,000 using ovenight incubation at 4 ℃ and sections that have been protease-digested or processed by high temperature antigen retrieval indirect immunofluorescence: 1:500 using overnight incubation at 4 ℃ |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | P01258 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CALCA(796) rat ... Calca(24241) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
