产品说明
应用
2-Chloro-2′-deoxyadenosine (2-CdA) is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias.
包装
10 mg in poly bottle
25 mg in glass bottle
生化/生理作用
Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity
基本信息
| 经验(实验)分子式 | C10H12ClN5O3 |
| 分子量 | 285.69 |
| MDL编号 | MFCD00153939 |
| PubChem化学物质编号 | 24892693 |
| NACRES | NA.51 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder or crystals |
| 储存温度 | 2-8℃ |
| SMILES string | Nc1nc(Cl)nc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3 |
| InChI | 1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1 |
| InChI key | PTOAARAWEBMLNO-KVQBGUIXSA-N |
| Gene Information | human ... NP(4860) rat ... Adora1(29290), Adora2a(25369), Adora3(25370) |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H301 - H341 - H361fd - H372 |
| 预防措施声明 | P201 - P202 - P260 - P264 - P270 - P301 + P310 |
| 危险分类 | Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
