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Caspase 9 human

品牌
Sigma-Aldrich
货号
C8726
规格纯度
≥90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine-tagged), buffered aqueous solution, >2,000 units/mg protein
参考价格
9414.2 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

25 μg in glass bottle

生化/生理作用

When cells receive apoptotic stimuli, such as activation of the TNFα/Fas cell surface receptor, caspase 8 activation, Bid processing and its translocation to the mitochondria ensue. As a result mitochondria release cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP. The resultant complex recruits caspase 9 leading to its activation. It then cleaves downstream caspases such as caspase 3, 6, and 7, initiating the caspase cascade. Caspase 9 exhibits basal activity. It can be further activated via interaction of its N-terminal prodomain with the activator protein Apaf-1 in the presence of cytochrome c and dATP. Caspases have been implicated in many disorders including cancer, inflammatory disease, neurodegenerative diseases, stroke and myocardial infarction.

单位定义

One unit will cleave 1.0 nmol of Ac-Leu-Glu-His-Asp-AFC per hr at 25 ℃ at pH 6.5.

外形

Solution in 10% sucrose containing 50 mM HEPES, pH 7.5, 5 mM DTT, 0.1% CHAPS, 1 mM EDTA, 50 mM NaCl.

基本信息

酶学委员会(EC)编号3.4.22.62 ( BRENDA | IUBMB )
MDL编号MFCD02687006

产品性质

质量水平200
重组expressed in E. coli (C-terminal histidine-tagged)
测定≥90% (SDS-PAGE)
形式buffered aqueous solution
specific activity>2,000 units/mg protein
分子量N-terminal prodomain plus the large subunit. 36 kDa (caspase 9 expressed as a C-terminal histidine-tagged protein appears as a two-subunit protein)
small subunit 13 kDa (subunit containing the histidine tag)
UniProt登记号P55211
运输dry ice
储存温度−70℃
Gene Informationhuman ... CASP9(842)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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