产品说明
特异性
Specifically recognizes a splice variant of γ4 (36.5 kDa) from human, mouse and rat.
免疫原
synthetic peptide derived from the rat γ4 calcium channel subunit conjugated to KLH.
应用
Anti-Calcium Channel (γ4 Subunit) (Voltage Gated Ca2+ Channel) antibody produced in rabbit is suitable for western blotting at a concentration of 5-10μg/mL using rat brain tissue lysate.
生化/生理作用
Voltage-dependent calcium channel γ-4 subunit is a protein encoded by the CACNG4 gene in humans and the three novel Ca2+ channel γ subunit genes (CACNG3, CACNG4, and CACNG5) are mapped on chromosome 16 and 17. It is a transmembrane protein that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazoleproponinc (AMPA) receptor regulatory proteins (TARPs). CACNG4 is found to be expressed in the CNS and display differential distributions among brain regions and several cell types in found in the cerebellum and hippocampus. It plays a key role in VDCC function. CACNG4 function as regulators of AMPA receptor localization and function in the brain and are collectively known as TARPs.
外形
Phosphate buffered saline containing 0.08% sodium azide.
基本信息
| MDL编号 | MFCD06201927 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | fractionated antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | mouse, rat, human |
| 浓度 | ~1 mg/mL |
| technique(s) | western blot: 5-10 μg/mL using rat brain tissue lysate |
| UniProt登记号 | Q9UBN1 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CACNG4(27092) mouse ... Cacng4(54377) rat ... Cacng4(140725) |
