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Monoclonal Anti-Na+/K+ ATPase (α Subunit) antibody produced in mouse

单克隆抗 Na + /K + atp 酶(α 亚单位) 小鼠抗

品牌
Sigma-Aldrich
货号
A276
规格纯度
clone M7-PB-E9, ascites fluid
参考价格
8300.37 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The Na+/K+ ATPase (NKA) enzyme contains α, β and γ subunits. This enzyme is widely expressed. ATPase Na+/K+ transporting subunit α 1 (ATP1A1) is a principal catalytic subunit of NKA. It has a molecular mass of about 110kDa with 10 transmembrane segments. α-subunit has four different isoforms with tissue specific expression. α1 is primarily expressed in various tissues, including kidney, nerves and lung. While α2 is expressed in skeletal muscle and heart, α3 is found in the brain and α4 is apparently localized to testis and specifically to spermatozoa. ATP1A1 is encoded by the gene mapped to human chromosome 1p13-p11.

免疫原

sheep kidney α subunit of Na+/K+ ATPase.

应用

Monoclonal Anti- Na+/K+ ATPase ( α Subunit) antibody produced in mouse has been used in flow cytometry.

生化/生理作用

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the α subunit, and an associated smaller glycoprotein, termed the β subunit. Studies indicate that there are three isoforms of the α subunit (α 1, α 2, α 3) and two isoforms of the β subunit (β 1 and β 2) encoded by two multigene families.
The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The α 1 and β mRNAs are present in all cell types examined, whereas the α 2 and α 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The α subunit has been found in kidney, brain, heart, and to a lesser extent liver, skeletal and smooth muscle.
The Na+/K+ ATPase is implicated in the maintenance of ion homeostasis for regular neuronal excitability, secondary transport and neurotransmitter uptake. ATPase Na+/K+ transporting subunit α 1 (ATP1A1) participates in both pumping and signaling functions. ATP1A1 regulates cellular transmembrane sodium and potassium ion gradients essential for the control of resting membrane potential. Additionally, nucleotide binding domain of ATP1A1 facilitates cellular signal transduction and cell growth. Deficiency of the gene leads to development of major depressive disorder (MDD).

目标描述

Na+/K+ transporting ATPase subunit α1 is an ion transport pump critical for maintaining the gradient of Na and K ions across the plasma membrane.

外形

solution containing 1 mg/ml BSA and 0.05% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02096998
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式ascites fluid
antibody product typeprimary antibodies
克隆M7-PB-E9, monoclonal
分子量antigen ~110 kDa
species reactivitypig, canine, bovine, sheep, chicken, human, mouse
should not react with rat, Xenopus
technique(s)immunocytochemistry: suitable
immunofluorescence: 1:20
immunohistochemistry (frozen sections): 1:100
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1:500-1:5000
同位素/亚型IgG1
UniProt登记号P05023
运输dry ice
储存温度−20℃
Gene Informationhuman ... ATP1A1(476)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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