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Anti-p75NTR (Neurotrophin Receptor) Antibody

品牌
Sigma-Aldrich
货号
07-476
规格纯度
Upstate®, from rabbit
参考价格
7197.66 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate.
The neurotrophins are comprised of four proteins, all of which bind to the LNGFR: Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4).
Nerve growth factor, the prototypical growth factor, is a protein secreted by a neuron′s target. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons.

特异性

Recognizes p75 neurotrophin receptor, MW ~75 kDa.

免疫原

Epitope: IC domain
GST fusion protein corresponding to the intracellular domain (residues 274-425) of rat p75 neurotrophin receptor.

应用

Detect p75NTR (Neurotrophin Receptor) using this Anti-p75NTR (Neurotrophin Receptor) Antibody validated for use in IH, IP & WB.
Research Sub Category
Neurochemistry & Neurotrophins
Immunoprecipitation:
This antibody has been reported by an independent laboratory to immunoprecipitate p75 neurotrophin receptor.

Immunohistochemistry:
This antibody has been reported by an independent laboratory to detect p75 neurotrophin receptor in rat brain sections. (Roux, P., 1999)
Research Category
Neuroscience

质量

Evaluated by western blot in RIPA lysates from PC-12 cells.

Western Blot Analysis:
0.1-0.5 µg/mL of this antibody detected p75 neurotrophin receptor in RIPA lysates from PC-12 cells.

目标描述

~75 kDa

外形

Format: Purified
Protein A purified
Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol.

储存及稳定性

Stable for 1 year at -20ºC from date of receipt.

分析说明

Control
Brain tissue.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆polyclonal
species reactivityhuman, mouse, rat
manufacturer/tradenameUpstate®
technique(s)immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型IgG
NCBI登记号NP_005028.4
UniProt登记号P07174
运输dry ice
Gene Informationhuman ... NGFR(4804)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1

Sigma-Aldrich

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