位置:首页 > 品牌 > Sigma-Aldrich >

Anti-JAK3 Antibody

品牌
Sigma-Aldrich
货号
07-1487
规格纯度
serum, from rabbit
参考价格
4848.93 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

JAKs are non-receptor tyrosine kinases which couple to cytokine receptors, and are activated by cytokines. JAK kinases (JAK1, JAK2, JAK3, Tyk2) have a kinase domain and a second, pseudokinase domain which is not enzymatically active. The principal effectors of JAKs are the STATs, which are direct activators of transcription, but JAKs also signal to the Ras-MAP Kinase pathway, and through Tec, to the PI3 Kinase pathway. JAK3 is required for signaling through cytokine receptors which share a common γ chain. JAK2 is required for signaling through a different subset of cytokine receptors, while JAK1 is essential for signaling from the IL-2, IL-6 and interferon receptors. The stress-activated protein kinase 1 (SAPK) family is also referred to as the jun N-terminal kinase family in light of the substrate preference of these serine/threonine kinases. In addition to regulating many biological processes including proliferation and apoptosis, the JNK/SAPK family has been implicated in many neurodegenerative diseases including Alzheimer disease, Parkinson′s disease and Amyotrophic lateral sclerosis.

特异性

Recognizes JAK3 (Janus Kinase 3).

免疫原

Synthetic peptide corresponding to amino acids 782-797 of mouse JAK3 (SDPTPGIPSPRDELC).

应用

Detect JAK3 using this Anti-JAK3 Antibody validated for use in WB & IP.
Immunoprecipitation: 5-10 uL of a previous lot of this antibody was used in immunoprecipitation.

Optimal working dilutions must be determined by end user.
Research Category
Signaling
Research Sub Category
Immunological Signaling

质量

Routinely evaluated by Western Blot on HeLa lysates.

Western Blot Analysis:
1:500 dilution of this lot detected JAK3 on 10 μg of HeLa lysates.

目标描述

125 kDa

联系

Replaces: AB3806

外形

Rabbit polyclonal IgG whole antiserum in buffer containing sodium azide.

储存及稳定性

Stable for 1 year at -20°C in undiluted aliquots from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
HeLa cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式serum
antibody product typeprimary antibodies
克隆polyclonal
species reactivitymouse, human
technique(s)immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型IgG
NCBI登记号NM_000215.2
UniProt登记号P52333
运输dry ice

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号