产品说明
一般描述
Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest.
应用
Application: Metabolomics research
基本信息
| 经验(实验)分子式 | C16H22ClN3 |
| 分子量 | 291.82 |
| MDL编号 | MFCD00871808 |
产品性质
| 质量水平 | 200 |
| 生物来源 | synthetic |
| 等级 | research grade |
| 测定 | ≥95% (HPLC) |
| 形式 | powder or crystals |
| technique(s) | HPLC: suitable |
| 颜色 | white to off-white |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| SMILES string | ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2 |
| InChI | 1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20) |
| InChI key | MCYUUUTUAAGOOT-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 预防措施声明 | P264 - P270 - P301 + P312 - P501 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
