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UA62784

品牌
Sigma-Aldrich
CAS
313367-92-9
货号
U3385
包装型号
规格纯度
≥98% (HPLC)
参考价格
1642.3 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

制备说明

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

基本信息

经验(实验)分子式C23H15NO3
分子量353.37
MDL编号MFCD00489199
PubChem化学物质编号329827627
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 yellow
溶解性DMSO: >2 mg/mL
储存温度2-8℃
SMILES stringCOc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
InChI1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
InChI keySVICLWPFAQYZLX-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
闪点(F)Not applicable
闪点(C)Not applicable

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