产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
制备说明
UA62784 is soluble in DMSO at a concentration >2 mg/ml.
基本信息
经验(实验)分子式 | C23H15NO3 |
分子量 | 353.37 |
MDL编号 | MFCD00489199 |
PubChem化学物质编号 | 329827627 |
NACRES | NA.77 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
颜色 | yellow |
溶解性 | DMSO: >2 mg/mL |
储存温度 | 2-8℃ |
SMILES string | COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34 |
InChI | 1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3 |
InChI key | SVICLWPFAQYZLX-UHFFFAOYSA-N |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H302 |
危险分类 | Acute Tox. 4 Oral |
储存分类代码 | 11 - Combustible Solids |
闪点(F) | Not applicable |
闪点(C) | Not applicable |