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XAP044

品牌
Sigma-Aldrich
CAS
196928-50-4
货号
SML1317
包装型号
规格纯度
≥98% (HPLC)
参考价格
5643.95 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7′s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.

其他说明

Light sensitive. This compound has Iodine and should be kept in the dark.

基本信息

经验(实验)分子式C15H9IO4
分子量380.13
MDL编号MFCD00525548
PubChem化学物质编号329825781

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件protect from light
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度2-8℃
SMILES stringO=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
InChI1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChI keyXXZKJJYWINSUMJ-UHFFFAOYSA-N

安全信息

储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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