产品说明
应用
Studies using TMPH have reported that it can alleviate the seizure-causing effect of levamisole. Additionally, it has been reported that TMPH does not induce behavioral changes in mice1.
包装
5, 25 mg in glass bottle
生化/生理作用
2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.
特点和优势
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
制备说明
TMPH hydrochloride is soluble in water at 22 mg/ml (at approx. 60° C).
基本信息
| 经验(实验)分子式 | C16H32ClNO2 |
| 分子量 | 305.88 |
| MDL编号 | MFCD08277030 |
| PubChem化学物质编号 | 24724633 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | (Product is pure based on CHN, NMR and MS results) |
| 形式 | solid |
| 储存条件 | under inert gas |
| 颜色 | white |
| 溶解性 | H2O: 22 mg/mL at ~60 ℃ |
| 储存温度 | 2-8℃ |
| SMILES string | Cl.CCCCCCC(=O)OC1CC(C)(C)NC(C)(C)C1 |
| InChI | 1S/C16H31NO2.ClH/c1-6-7-8-9-10-14(18)19-13-11-15(2,3)17-16(4,5)12-13;/h13,17H,6-12H2,1-5H3;1H |
| InChI key | XIDDVJIJIFWGIX-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H317 - H319 - H335 |
| 预防措施声明 | P280 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
