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WWL229

品牌
Sigma-Aldrich
CAS
1338575-28-2
货号
SML1180
规格纯度
≥98% (HPLC)
参考价格
1396.09 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.

基本信息

经验(实验)分子式C16H22N2O5
分子量322.36
PubChem化学物质编号329825704

产品性质

质量水平100
测定≥98% (HPLC)
形式oil
颜色 colorless to light yellow
储存温度2-8℃
SMILES stringO=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2
InChI1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
InChI keyXVBRVSAGMWRVCK-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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