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Oncostatin M human

抑癌蛋白 M 人

品牌
Sigma-Aldrich
CAS
106956-32-5
货号
H6541
规格纯度
OSM, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
参考价格
6257.39 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.

外形

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

分析说明

The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

法律信息

HumanKine is a registered trademark of Proteintech Group, Inc.

基本信息

MDL编号MFCD00166731
NACRESNA.77

产品性质

质量水平100
生物来源human
重组expressed in HEK 293 cells
测定≥95% (SDS-PAGE)
形式lyophilized powder
效能≤1 ng/mL EC50
质量endotoxin tested
分子量dimer 30 kDa (glycosylated)
包装pkg of 5X10 μg
pkg of 10 μg
technique(s)cell culture | mammalian: suitable
杂质≤1 EU/μg
UniProt登记号P13725
储存温度−20℃
Gene Informationhuman ... OSM(5008)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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