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TFLLR-NH2 trifluoroacetate salt

品牌
Sigma-Aldrich
货号
T7830
规格纯度
>98% (HPLC)
参考价格
1698.93 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

应用

TFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

包装

5, 25 mg in glass bottle

生化/生理作用

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

制备说明

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

基本信息

经验(实验)分子式C31H53N9O6 · xC2HF3O2
分子量647.81 (free base basis)
MDL编号MFCD05663482
PubChem化学物质编号329826874
NACRESNA.77

产品性质

质量水平100
测定>98% (HPLC)
形式lyophilized powder
颜色 white to tan
溶解性H2O: >2 mg/mL
储存温度−20℃
SMILES stringOC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
InChI1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
InChI keyQVNWOGSDGQDGHP-MKVNCOEFSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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