产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
WZ4003 helps to repress the migration of cells. It also prevents cell proliferation.
WZ4003 is a potent and selective inhibitor of NUAK1 and NUAK2 kinases, members of the AMPK family that are that are activated by the LKB1 (liver kinase B1) tumour suppressor kinase and involved in development and proliferation. WZ4003 has an IC50 of 20 nM for NUAK1 and an IC50 of 100 nM for NUAK2 without significant inhibition of 139 other kinases tested, including ten AMPK-related kinase family members. Treatment with WZ4003 was found to suppress proliferation, restricting cells from entering into mitosis.
其他说明
WZ4003 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the WZ4003 probe summary on the Chemical Probes Portal website.
基本信息
| 经验(实验)分子式 | C25H29ClN6O3 |
| 分子量 | 496.99 |
| MDL编号 | MFCD28015100 |
| PubChem化学物质编号 | 329825885 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 5 mg/mL, clear (warmed) |
| 储存温度 | −20℃ |
| SMILES string | ClC1=CN=C(NC2=C(OC)C=C(N3CCN(C)CC3)C=C2)N=C1OC4=CC(NC(CC)=O)=CC=C4 |
| InChI | 1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30) |
| InChI key | SDGJBAUIGHSMRI-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 预防措施声明 | P301 + P312 + P330 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
