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SB 415286

品牌
Sigma-Aldrich
CAS
264218-23-7
货号
S3567
规格纯度
≥98% (HPLC)
参考价格
2085.96 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.

包装

5, 25 mg in glass bottle

生化/生理作用

SB 415286 is a small molecule inhibitor of GSK-3 in muscle and fat cells. SB 415286 induces activation of glycogen synthase and regulates the transport glucose. SB 415286 reduces the systemic inflammation induced by endotoxic shock in rat model of acute colitis. It increases the axonal growth and promotes the recovery of injured adult CNS neurons. SB 415289 is implicated in inducing chromosome instability when used as therapeutic agents.
Glycogen synthase kinase-3 (GSK-3) inhibitor.

特点和优势

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from GlaxoSmithKline.

基本信息

经验(实验)分子式C16H10N3O5Cl
分子量359.72
MDL编号MFCD04039789
PubChem化学物质编号24278412

产品性质

质量水平100
测定≥98% (HPLC)
颜色 yellow to orange
溶解性DMSO: 5 mg/mL, clear
H2O: insoluble
创始人GlaxoSmithKline
储存温度−20℃
SMILES stringOc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl
InChI1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
InChI keyPQCXVIPXISBFPN-UHFFFAOYSA-N
Gene Informationhuman ... GSK3A(2931), GSK3B(2932)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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