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TCS 401

品牌
Sigma-Aldrich
货号
SML2140
规格纯度
≥98% (HPLC)
参考价格
1468.82 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B), which plays a key role in the negative regulation of the insulin signaling pathway, contributing to insulin resistance. It exhibited Ki values of 290 nM for PTP1B, with greater than 100-fold or more selectivity compared to other phosphatases. Inhibition of PTP1B by TCS 401 has been shown to sensitize the insulin signaling pathway and increase dopamine release in response to insulin. TCS-401 has also been shown to promote endothelial cell motility and to induce differentiation of retinal pigment epithelial cells toward improved contractility and motility.

基本信息

经验(实验)分子式C10H10N2O5S · xHCl
分子量270.26 (free base basis)
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性0.1 M NaOH: 2 mg/mL, clear (warmed)
储存温度2-8℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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