产品说明
应用
Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.
包装
25 mg in poly bottle
生化/生理作用
Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.
EGFR tyrosine kinase inhibitor.
特点和优势
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
制备说明
Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.
基本信息
| 线性分子式 | CH3OC6H4CH=C(CN)2 |
| 分子量 | 184.19 |
| MDL编号 | MFCD00019787 |
| PubChem化学物质编号 | 24278751 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥98% |
| 形式 | solid |
| 效能 | >1250 μM IC50 (negative control) |
| mp | 113-116 ℃ (lit.) |
| 溶解性 | chloroform: soluble 50 mg/mL, clear, light yellow DMSO: soluble |
| 储存温度 | 2-8℃ |
| SMILES string | COc1ccc(cc1)\C=C(/C#N)C#N |
| InChI | 1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3 |
| InChI key | UOHFCPXBKJPCAD-UHFFFAOYSA-N |
| Gene Information | human ... EGFR(1956) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
