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Tyrphostin 1

品牌
Sigma-Aldrich
CAS
2826-26-8
货号
T7040
包装型号
规格纯度
≥98%
参考价格
2104.92 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.

包装

25 mg in poly bottle

生化/生理作用

Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.
EGFR tyrosine kinase inhibitor.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

制备说明

Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.

基本信息

线性分子式CH3OC6H4CH=C(CN)2
分子量184.19
MDL编号MFCD00019787
PubChem化学物质编号24278751
NACRESNA.77

产品性质

质量水平200
测定≥98%
形式solid
效能>1250 μM IC50 (negative control)
mp113-116 ℃ (lit.)
溶解性chloroform: soluble 50 mg/mL, clear, light yellow
DMSO: soluble
储存温度2-8℃
SMILES stringCOc1ccc(cc1)\C=C(/C#N)C#N
InChI1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
InChI keyUOHFCPXBKJPCAD-UHFFFAOYSA-N
Gene Informationhuman ... EGFR(1956)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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