产品说明
应用
BD 1047, a selective, putative σ1 receptor antagonist, is used in sigma receptor research to help differentiate and characterized the function and role of the sigma1 receptor versus other sigma receptor subtypes. BD 1047 is used to help define the role of σ1 receptors in neurological processes.
BD 1047 dihydrobromide has been used as an antagonist of sigma-1 receptor in hepatocellular carcinoma cells.
包装
5, 25 mg in glass bottle
生化/生理作用
In human immunodeficiency (HIV)-1 seropositive patients, BD 1047 along with other antioxidants may aid in reduction of cathepsin B- based neuropathology.
BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- & α2-adrenoceptor, 5-HT1, and 5-HT2. Though s receptor antagonism is consistent with antipsychotic, especially anti-schizophrenic, activity, BD-1047 shows only modest activity in animal screens for antipsychotics.
基本信息
| 经验(实验)分子式 | C13H20Cl2N2 · 2 HBr |
| 分子量 | 437.04 |
| MDL编号 | MFCD00792739 |
| PubChem化学物质编号 | 329773309 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | powder |
| 颜色 | white |
| 溶解性 | H2O: >5 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1 |
| InChI | 1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H |
| InChI key | WOALTFHGLDVJHK-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H315 - H318 - H335 |
| 预防措施声明 | P280 - P302 + P352 - P305 + P351 + P338 + P310 |
| 危险分类 | Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
