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AG-09/1

品牌
Sigma-Aldrich
CAS
356776-32-4
货号
A9486
包装型号
规格纯度
≥98% (HPLC)
参考价格
7836.79 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

AG-09/1 is a selective formyl peptide receptor 1 (FPR1) agonist; it activates chemotaxis in human neutrophils. Formyl peptide recetors (FPRs) are GPCRs mainly expressed in phagocytic leukocytes but with lower expression in many other cell types. Formyl peptides, act as Alarmins and are released from bacteria and damaged mitochondria, serving as chemoattractants for phagocyte recruitment to sites of inflammation, resulting in immune response. Because the endogenous ligands for FPRs are peptides and arachidonic acid metabolites, there are few small molecule tools for these receptors. A recent HTS of commercially available libraries yielded several FPR-1 selective agonists, of which AG-091 was the most potent. AG-091 induced intracellular calcium flux in FPR-1- but not FPR-2-expressing cells. It also caused chemotaxis and intracellular calcium flux in human leukocytes. AG-091 is a valuable tool for studying FPR1 function in immune and other disease states.

基本信息

经验(实验)分子式C16H14N4O4S
分子量358.37
MDL编号MFCD02321063
PubChem化学物质编号329771051
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 yellow to brown
溶解性DMSO: ≥30 mg/mL
储存温度2-8℃
SMILES stringCOc1ccc2[nH]c(SCC(=O)Nc3ccc(cc3)[N+]([O-])=O)nc2c1
InChI1S/C16H14N4O4S/c1-24-12-6-7-13-14(8-12)19-16(18-13)25-9-15(21)17-10-2-4-11(5-3-10)20(22)23/h2-8H,9H2,1H3,(H,17,21)(H,18,19)
InChI keyLYQDSNOFTIZWAX-UHFFFAOYSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H318
预防措施声明P280 - P305 + P351 + P338
危险分类Eye Dam. 1
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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